Chronic inhibition of brain glycolysis initiates epileptogenesis.

  title={Chronic inhibition of brain glycolysis initiates epileptogenesis.},
  author={E Samokhina and Irina Popova and Anton E Malkov and Anton I. Ivanov and Daniela Papadia and Alexander Osypov and Maxim Molchanov and Svetlana I. Paskevich and Andr{\'e} Fisahn and Misha Zilberter and Yuri Zilberter},
  journal={Journal of neuroscience research},
  volume={95 11},
Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a causal link between deficient brain energy metabolism and epilepsy initiation has not been yet established. To address this issue we developed an in vivo model of chronic energy… CONTINUE READING
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