Chronic inhibition of brain glycolysis initiates epileptogenesis.

@article{Samokhina2017ChronicIO,
  title={Chronic inhibition of brain glycolysis initiates epileptogenesis.},
  author={E Samokhina and Irina Popova and Anton E Malkov and Anton I. Ivanov and Daniela Papadia and Alexander Osypov and Maxim Molchanov and Svetlana I. Paskevich and Andr{\'e} Fisahn and Misha Zilberter and Yuri Zilberter},
  journal={Journal of neuroscience research},
  year={2017},
  volume={95 11},
  pages={
          2195-2206
        }
}
Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a causal link between deficient brain energy metabolism and epilepsy initiation has not been yet established. To address this issue we developed an in vivo model of chronic energy… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 18 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Hungry Neurons: Metabolic Insights on Seizure Dynamics

International journal of molecular sciences • 2017
View 5 Excerpts
Highly Influenced

Bioenergetic Mechanisms of Seizure Control

Front. Cell. Neurosci. • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 53 references

How does the ketogenic diet induce anti-seizure effects?

Neuroscience letters • 2017
View 1 Excerpt
Highly Influenced

Neurometabolism in human epilepsy.

Epilepsia • 2008
View 4 Excerpts
Highly Influenced

Epilepsy treatment

N Sada, S Lee, T Katsu, T Otsuki, T. Inoue
Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 347:1362–1367. • 2015

Similar Papers

Loading similar papers…