Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat.

@article{Horton1988ChronicIO,
  title={Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat.},
  author={Roger W. Horton and Nancy J. Rothwell and Michael J. Stock},
  journal={General pharmacology},
  year={1988},
  volume={19 3},
  pages={403-5}
}
1. Oral administration of the GABA transaminase inhibitor ethanolamine-O-sulphate (EOS, 5 mg/ml in drinking water) to rats for 14 days suppressed food intake by 24%, but reduced weight gain by over 35%. 2. Thus, feed efficiency (g gain/MJ eaten) was decreased by over 15% in EOS-treated rats, suggesting that there had been an increase in metabolic rate. 3… CONTINUE READING