Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats.

@article{Roos1996ChronicIN,
  title={Chronic inhaled nitric oxide: effects on pulmonary vascular endothelial function and pathology in rats.},
  author={Carel M Roos and Dr. rer nat. U. Frank and Chang-hu Xue and Roger A. Johns and George Frederick Rich},
  journal={Journal of applied physiology},
  year={1996},
  volume={80 1},
  pages={252-60}
}
Nitric oxide (NO) is a potent endogenous vasodilator produced in endothelial cells. Inhaled NO selectively vasodilates the pulmonary circulation. We determined the effects of chronic inhaled NO on hypoxic pulmonary vascular remodeling and endothelium NO-dependent and -independent vasodilation during normoxic and hypoxic conditions in rats. Rats were exposed to 3 wk of normoxia (N), normoxia + 20 ppm inhaled NO (N+NO), chronic hypoxia with 10% normobaric oxygen (CH), or CH and 20 ppm inhaled NO… CONTINUE READING