Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar rats.

@article{Reuzel1991ChronicIT,
  title={Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar rats.},
  author={Paul G. J. Reuzel and H C Dreef-van der Meulen and Victor M. H. Hollanders and Christine F. Kuper and Victor J. Feron and C A van der Heijden},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1991},
  volume={29 1},
  pages={
          31-9
        }
}
The toxicity and carcinogenicity of methyl bromide (MeBr) were studied in male and female Wistar rats exposed by inhalation to 0, 3, 30 or 90 ppm MeBr 6hr/day, 5 days/wk for 29 months. After 13, 52 and 104 wk ten rats/sex/group were killed to provide interim information. Body weights, clinical signs, haematology, biochemistry and gross and microscopic pathology were studied. Mortality was increased by wk 114 in the 90-ppm group. Body weights in males and females of the 90-ppm group were lower… CONTINUE READING
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