Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine.

@article{Beaumont2017ChronicIO,
  title={Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine.},
  author={Ross E Beaumont and Philip A A Cordery and Mark P Funnell and Stephen A. Mears and Lewis John James and Phillip Lowell Watson},
  journal={Journal of sports sciences},
  year={2017},
  volume={35 19},
  pages={
          1920-1927
        }
}
This study examined effects of 4 weeks of caffeine supplementation on endurance performance. Eighteen low-habitual caffeine consumers (<75 mg · day-1) were randomly assigned to ingest caffeine (1.5-3.0 mg · kg-1day-1; titrated) or placebo for 28 days. Groups were matched for age, body mass, V̇O2peak and Wmax (P > 0.05). Before supplementation, all participants completed one V̇O2peak test, one practice trial and 2 experimental trials (acute 3 mg · kg-1 caffeine [precaf] and placebo [testpla… CONTINUE READING

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