Chronic infusion of nicotine can increase operant self-administration of alcohol

@article{Clark2001ChronicIO,
  title={Chronic infusion of nicotine can increase operant self-administration of alcohol},
  author={Andrew R. Clark and Sune Lindgren and S. P. Brooks and William P. Watson and Hilary J. Little},
  journal={Neuropharmacology},
  year={2001},
  volume={41},
  pages={108-117}
}
Effects of nicotine, administered by continuous infusion via osmotic minipumps, were studied on the operant self-administration of alcohol by rats, using a variable interval (15 s) schedule, and measuring the acquisition, maintenance, extinction and reinstatement of responding for alcohol. Doses of nicotine of 0.25, 1.25 and 7.5 mg/kg/24 h had no significant effects on the maintenance of responding for alcohol, but 5 mg/kg/24 h nicotine resulted in a significant increase in responding on the… CONTINUE READING
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