Chronic infusion of nicotine can increase operant self-administration of alcohol

  title={Chronic infusion of nicotine can increase operant self-administration of alcohol},
  author={Andrew R. Clark and Sune Lindgren and S. P. Brooks and William P. Watson and Hilary J. Little},
Effects of nicotine, administered by continuous infusion via osmotic minipumps, were studied on the operant self-administration of alcohol by rats, using a variable interval (15 s) schedule, and measuring the acquisition, maintenance, extinction and reinstatement of responding for alcohol. Doses of nicotine of 0.25, 1.25 and 7.5 mg/kg/24 h had no significant effects on the maintenance of responding for alcohol, but 5 mg/kg/24 h nicotine resulted in a significant increase in responding on the… CONTINUE READING
Highly Cited
This paper has 70 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 35 extracted citations

Nicotine modulates alcohol-seeking and relapse by alcohol-preferring (P) rats in a time-dependent manner.

Alcoholism, clinical and experimental research • 2012
View 4 Excerpts
Highly Influenced

71 Citations

Citations per Year
Semantic Scholar estimates that this publication has 71 citations based on the available data.

See our FAQ for additional information.