Chronic infusion of SOD1G93A astrocyte‐secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats

@article{RamrezJarqun2017ChronicIO,
  title={Chronic infusion of SOD1G93A astrocyte‐secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats},
  author={U. N. Ram{\'i}rez-Jarqu{\'i}n and F. Rojas and B. van Zundert and R. Tapia},
  journal={Journal of Cellular Physiology},
  year={2017},
  volume={232},
  pages={2610 - 2615}
}
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non‐cell‐autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were treated with conditioned media derived from primary mouse astrocytes (ACM) that express… Expand
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