Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.

@article{Voutilainen2011ChronicIO,
  title={Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.},
  author={Merja H Voutilainen and Susanne B{\"a}ck and Johan Per{\"a}nen and P{\"a}ivi Lindholm and Atso Raasmaja and Pekka T. M{\"a}nnist{\"o} and Mart Saarma and Raimo K. Tuominen},
  journal={Experimental neurology},
  year={2011},
  volume={228 1},
  pages={99-108}
}
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) constitute a novel, evolutionarily conserved family of neurotrophic factors (NTF) expressed in vertebrates and invertebrates. The effects of two-week infusions of CDNF, MANF and glial cell line-derived neurotrophic factor (GDNF) were studied in a rat 6-hydroxydopamine (6-OHDA) hemiparkinsonian model. Degeneration of nigrostriatal dopamine nerve tract after toxin injection was assessed by… CONTINUE READING