Chronic inflammatory pain does not attenuate the development of tolerance to chronic morphine in adult male rats.

@article{Uhelski2011ChronicIP,
  title={Chronic inflammatory pain does not attenuate the development of tolerance to chronic morphine in adult male rats.},
  author={Megan L. Uhelski and Jessica A. Boyette-Davis and Perry N. Fuchs},
  journal={Pharmacology, biochemistry, and behavior},
  year={2011},
  volume={98 2},
  pages={325-30}
}
The overall impact of chronic pain on the response to opioids is ambiguous in the literature, and comparisons between human and animal studies are complicated by vast differences between the manner and dosage of opioids given to humans treated for pain in comparison to rodents as well as a lack of healthy participant studies examining the impact of chronic opioids. The purpose of this study was to evaluate the impact of chronic pain on the development of tolerance to morphine and to assess how… CONTINUE READING