Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis.

@article{Lueth2011ChronicII,
  title={Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis.},
  author={Stefan Lueth and J{\"o}rg von Schrader and Stefan Zander and Antonella Carambia and Juliane Buchkremer and Samuel Huber and Kurt Reifenberg and Ken-ichi Yamamura and Peter Schirmacher and Ansgar W Lohse and Johannes Herkel},
  journal={Cancer research},
  year={2011},
  volume={71 11},
  pages={
          3763-71
        }
}
Chronic liver inflammation is a critical component of hepatocarcinogenesis. Indeed, inflammatory mediators are believed to promote liver cancer by upholding compensatory proliferation of hepatocytes in response to tissue damage. However, inflammation can also mediate the depletion of malignant cells, but the difference between tumor-suppressive and tumor-promoting inflammation is not defined at the molecular level. Here, we analyzed the role of the major inflammatory mediator IFN-γ in chemical… CONTINUE READING

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