Chronic inflammation caused by lymphotoxin is lymphoid neogenesis

  title={Chronic inflammation caused by lymphotoxin is lymphoid neogenesis},
  author={A Kratz and Antonio Campos-Neto and Matthew S. Hanson and Nancy H. Ruddle},
  journal={The Journal of Experimental Medicine},
  pages={1461 - 1472}
In presenting a unifying concept for chronic inflammation and lymphoid organogenesis, we suggest that lymphotoxin's (LT, LT-alpha, TNF-beta) crucial role in these processes is pivotal and similar. Chronic inflammatory lesions that developed in the kidney and pancreas at the sites of transgene expression in rat insulin promoter-LT (RIP-LT) mice resembled lymph nodes with regard to cellular composition (T cells, B cells, plasma cells, and antigen-presenting cells), delineated T and B cell areas… CONTINUE READING
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