Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma.

@article{Matsuzaki2007ChronicIA,
  title={Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma.},
  author={Koichi Matsuzaki and Miki Murata and Katsunori Yoshida and Go Sekimoto and Yoshiko Uemura and Noriko Sakaida and Masaki Kaibori and Yasuo Kamiyama and Mikio Nishizawa and Junichi Fujisawa and Kazuichi Okazaki and Toshihito Seki},
  journal={Hepatology},
  year={2007},
  volume={46 1},
  pages={48-57}
}
UNLABELLED Many patients with chronic hepatitis caused by hepatitis C virus (HCV) infection develop liver fibrosis with high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear. Conversely, transforming growth factor beta (TGF-beta) activates not only TGF-beta type I receptor (TbetaRI) but also c-Jun N-terminal kinase (JNK), which convert the mediator Smad3 into two distinctive phosphoisoforms: C-terminally phosphorylated Smad3 (pSmad3C) and linker… CONTINUE READING

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