Chronic increases in transmural pressure reduce NO-mediated dilations in isolated resistance arteries of the hamster.


It is unclear whether the impairment of NO-mediated dilation in hypertension is the cause or the consequence of high blood pressure. We therefore studied in isolated resistance arteries whether elevated transmural pressure affects NO-mediated dilation. Arteries (n=5-7) were perfused at hydrostatic pressures of either 45, 120 or 160 mmHg for 48 h… (More)


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