Chronic hypoxia induces proliferation of cultured mesangial cells: role of calcium and protein kinase C.

@article{Sahai1997ChronicHI,
  title={Chronic hypoxia induces proliferation of cultured mesangial cells: role of calcium and protein kinase C.},
  author={Atul Sahai and Changlin Mei and Timothy A Pattison and Richard L Tannen},
  journal={The American journal of physiology},
  year={1997},
  volume={273 6 Pt 2},
  pages={F954-60}
}
The effect of hypoxia on the proliferation of cultured rat mesangial cells was examined. To evaluate the underlying signaling mechanisms, the roles of intracellular calcium ([Ca2+]i) and protein kinase C (PKC) were determined. Quiescent cultures were exposed to hypoxia (3% O2) or normoxia (18% O2), and [3H]thymidine incorporation, cell number, [Ca2+]i, and PKC were assessed. Mesangial cells exposed to 28 h of hypoxia exhibited a significant increase in [3H]thymidine incorporation followed by a… CONTINUE READING