Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery.

@article{Bonnet2001ChronicHS,
  title={Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery.},
  author={S{\'e}bastien Bonnet and J M Hyvelin and Pierre Bonnet and Roger Marthan and J. P. Savineau},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 1},
  pages={L183-92}
}
The effect of chronic hypoxia (CH; 1-4 wk) on the electromechanical properties of the rat main pulmonary artery (MPA) was investigated. MPA rings obtained from rats exposed for 14 days to hypobaric (50.5 kPa) CH exhibited spontaneous and rhythmic contractions (SRCs) that were never observed in control (normoxic) rats. SRCs were unaffected by tetrodotoxin, phentolamine, BQ-123 and BQ-788, N-nitro-L-arginine methyl ester, or endothelium removal. CH depolarized smooth muscle cells from -58.8 +/- 9… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…