Chronic hypoxia decreases K(V) channel expression and function in pulmonary artery myocytes.

@article{Platoshyn2001ChronicHD,
  title={Chronic hypoxia decreases K(V) channel expression and function in pulmonary artery myocytes.},
  author={Oleksandr Platoshyn and Ying Di Yu and Vera A. Golovina and Sharon S. McDaniel and Stefanie Krick and Li Li and Jin Ye Wang and Lewis J. Rubin and Jason X-J Yuan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 4},
  pages={L801-12}
}
Activity of voltage-gated K+ (KV) channels regulates membrane potential (E(m)) and cytosolic free Ca2+ concentration ([Ca2+](cyt)). A rise in ([Ca2+](cyt))in pulmonary artery (PA) smooth muscle cells (SMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation. Chronic hypoxia (PO(2) 30-35 mmHg for 60-72 h) decreased mRNA expression of KV channel alpha-subunits (Kv1.1, Kv1.5, Kv2.1, Kv4.3, and Kv9.3) in PASMCs but not in mesenteric artery (MA) SMCs. Consistently, chronic… CONTINUE READING
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