Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.

@article{Broughton2010ChronicHA,
  title={Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.},
  author={Brad R. S. Broughton and Nikki L Jernigan and Charles E Norton and Benjimen R. Walker and Thomas C. Resta},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2010},
  volume={298 2},
  pages={L232-42}
}
Rho kinase (ROCK)-dependent vasoconstriction has been implicated as a major factor in chronic hypoxia (CH)-induced pulmonary hypertension. This component of pulmonary hypertension is associated with arterial myogenicity and increased vasoreactivity to receptor-mediated agonists and depolarizing stimuli resulting from ROCK-dependent myofilament Ca(2+) sensitization. On the basis of separate lines of evidence that CH increases pulmonary arterial superoxide (O(2)(-)) generation and that O(2… CONTINUE READING

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