Chronic hypoxia- and cold-induced changes in cardiac enzyme and gene expression in CD-1 mice.

@article{Templeman2010ChronicHA,
  title={Chronic hypoxia- and cold-induced changes in cardiac enzyme and gene expression in CD-1 mice.},
  author={Nicole M. Templeman and Jacqueline L. Beaudry and Christophe M R Le Moine and Grant B. McClelland},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1800 12},
  pages={1248-55}
}
BACKGROUND In mammals, environmental challenges often result in physical and metabolic cardiac remodeling (i.e., hypertrophy and a shift from lipid to carbohydrate oxidation). While chronic hypoxia and cold are both known to elicit cardiac changes, little is known about their combined effects. METHODS To investigate the cumulated effects of these two stressors on cardiac physiology, CD-1 mice were exposed for 4 weeks to normoxia/normothermia, hypoxia, cold, or combined hypoxic-cold. We… CONTINUE READING

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