Chronic hypoxia alters effects of endothelin and angiotensin on K+ currents in pulmonary arterial myocytes.

@article{Shimoda1999ChronicHA,
  title={Chronic hypoxia alters effects of endothelin and angiotensin on K+ currents in pulmonary arterial myocytes.},
  author={Larissa A. Shimoda and Joseph Sylvester and James S K Sham},
  journal={The American journal of physiology},
  year={1999},
  volume={277 3},
  pages={
          L431-9
        }
}
We tested the hypothesis that chronic hypoxia alters the regulation of K+ channels in intrapulmonary arterial smooth muscle cells (PASMCs). Charybdotoxin-insensitive, 4-aminopyridine-sensitive voltage-gated K+ (K(V,CI)) and Ca2+-activated K+ (KCa) currents were measured in freshly isolated PASMCs from rats exposed to 21 or 10% O2 for 17-21 days. In chronically hypoxic PASMCs, K(V, CI) current was reduced and KCa current was enhanced. 4-Aminopyridine (10 mM) depolarized both normoxic and… CONTINUE READING

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