Chronic hypertension induced by streptozotocin in rats

  title={Chronic hypertension induced by streptozotocin in rats},
  author={Hidetoshi Kawashima and Toshiji Igarashi and Yoshikage Nakajima and Yasuhiro Akiyama and Kazuyasu Usuki and Shinzaburo Ohtake},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
An intravenous injection of 40 or 65 mg/kg streptozotocin induced not only diabetes but also severe hypertension in rats. Whereas the hyperglycemia developed fully within a few days after the injection of streptozotocin, the hypertension progressively advanced and reached maximum level several weeks after the treatment and lasted more than 20 weeks. Twenty mg/kg streptozotocin did not induce hyperglycemia but significantly increased blood pressure several weeks after the treatment. Arrest of… CONTINUE READING
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