Chronic hypersensitivity pneumonitis produced in the rabbit by the adjuvant effect of inhaled muramyl dipeptide (MDP).

@article{Richerson1982ChronicHP,
  title={Chronic hypersensitivity pneumonitis produced in the rabbit by the adjuvant effect of inhaled muramyl dipeptide (MDP).},
  author={Hal B. Richerson and M T Suelzer and Priscilla A Swanson and John E. Butler and William C Kopp and Earl F. Rose},
  journal={The American journal of pathology},
  year={1982},
  volume={106 3},
  pages={409-20}
}
An established rabbit model of acute hypersensitivity pneumonitis was used to evaluate adjuvant properties of synthetic muramyl dipeptide (MDP), the minimal adjuvant-active structure of mycobacteria. The authors studied MDP as a substitute for mycobacteria in immunization and as adjuvant during repeated inhalation of antigen (ovalbumin). They found that MDP could substitute successfully for mycobacteria in sensitizing animals for acute alveolitis following subsequent inhalation of a combination… CONTINUE READING