Chronic hyperosmolality increases NHE3 activity in OKP cells.

  title={Chronic hyperosmolality increases NHE3 activity in OKP cells.},
  author={Patrice M Amb{\"u}hl and Morimasa Amemiya and Patricia A. Preisig and Orson W Moe and Robert J. Alpern},
  journal={The Journal of clinical investigation},
  volume={101 1},
This study investigated the effect of chronic hypertonicity on the OKP cell Na/H antiporter, encoded by Na/H exchanger 3 (NHE3). Chronic (48 h) increases in extracellular glucose, mannitol, or raffinose concentration caused a significant increase in Na/H antiporter activity, while increases in urea concentration were without effect. This effect was seen with changes in osmolality of only 20 mOsm/liter, a magnitude that is observed clinically in poorly controlled diabetes mellitus. Increases in… CONTINUE READING
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