Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes.

@article{Aas2011ChronicHR,
  title={Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes.},
  author={Vigdis Aas and Nina Pettersen Hessvik and Marianne Wettergreen and Andreas W Hvammen and Stefan Hall{\'e}n and Gunn Hege Thoresen and Arild C Rustan},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1812 1},
  pages={94-105}
}
Skeletal muscle of insulin resistant individuals is characterized by lower fasting lipid oxidation and reduced ability to switch between lipid and glucose oxidation. The purpose of the present study was to examine if chronic hyperglycemia would impair metabolic switching of myotubes. Human myotubes were treated with or without chronic hyperglycemia (20mmol/l glucose for 4 days), and metabolism of [(14)C]oleic acid (OA) and [(14)C]glucose was studied. Myotubes exposed to chronic hyperglycemia… CONTINUE READING

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