Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

@article{Kjrholt2005ChronicHI,
  title={Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.},
  author={Cecilie Kj{\o}rholt and Mia C. {\AA}kerfeldt and Trevor J Biden and D. Ross Laybutt},
  journal={Diabetes},
  year={2005},
  volume={54 9},
  pages={
          2755-63
        }
}
The beta-cell is a highly specialized cell with a unique differentiation that optimizes glucose-induced insulin secretion (GIIS). Here, we evaluated changes in gene expression that accompany beta-cell dysfunction in the db/db mouse model of type 2 diabetes. In db/db islets, mRNA levels of many genes implicated in beta-cell glucose sensing were progressively reduced with time, as were several transcription factors important for the maintenance of beta-cell differentiation. Conversely, genes… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS, ESTIMATED 43% COVERAGE

p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

  • Molecular endocrinology
  • 2009
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND

Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.

  • Diabetes, obesity & metabolism
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is LOSS OF -CELL DIFFERENTIATION IN db/db MICE

C Bonny, R Roduit, +3 authors G Waeber
  • DIABETES,
  • 2005
VIEW 1 EXCERPT

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 1 EXCERPT