Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats.

@article{Ahabrach2010ChronicHA,
  title={Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats.},
  author={Hanan Ahabrach and Blanca Piedrafita and A. Ayad and Nisrin El Mlili and Mohammed Errami and Vicente Felipo and Marta Llansola},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 7},
  pages={1605-14}
}
Patients with liver cirrhosis may present hepatic encephalopathy with a wide range of neurological disturbances and alterations in sleep quality and in the sleep-wake circadian rhythm. Hyperammonemia is a main contributor to the neurological alterations in hepatic encephalopathy. We have assessed, in an animal model of chronic hyperammonemia without liver failure, the effects of hyperammonemia per se on the circadian rhythms of motor activity, temperature, and plasma levels of adrenal… CONTINUE READING