Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1

@article{Sluka2003ChronicHI,
  title={Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1},
  author={Kathleen A Sluka and Margaret P. Price and Nicole M Breese and Cheryl L Stucky and Michael J. Welsh},
  journal={Pain},
  year={2003},
  volume={106},
  pages={229-239}
}
Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult to treat. Cellular and molecular mechanisms underlying chronic muscle-induced hyperalgesia are not well understood. For this reason, we developed an animal model where repeated injections of acidic saline into one gastrocnemius muscle produce bilateral, long-lasting mechanical hypersensitivity of the paw (i.e. hyperalgesia) without associated tissue damage. Since acid sensing ion channels (ASICs) are… CONTINUE READING
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