Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

@article{Ng2010ChronicHD,
  title={Chronic high-fat diet in fathers programs $\beta$-cell dysfunction in female rat offspring},
  author={Sheau-Fang Ng and Ruby C Y Lin and David Ross Laybutt and Romain Barr{\`e}s and Julie A Owens and Margaret J. Morris},
  journal={Nature},
  year={2010},
  volume={467},
  pages={963-966}
}
The global prevalence of obesity is increasing across most ages in both sexes. This is contributing to the early emergence of type 2 diabetes and its related epidemic. Having either parent obese is an independent risk factor for childhood obesity. Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established, the extent of any contribution of obese fathers is unclear, particularly the role of non-genetic factors in the causal… 

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