Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

@article{Ng2010ChronicHD,
  title={Chronic high-fat diet in fathers programs $\beta$-cell dysfunction in female rat offspring},
  author={Sheau-Fang Ng and Ruby C Y Lin and David Ross Laybutt and Romain Barr{\`e}s and Julie A Owens and Margaret J. Morris},
  journal={Nature},
  year={2010},
  volume={467},
  pages={963-966}
}
The global prevalence of obesity is increasing across most ages in both sexes. This is contributing to the early emergence of type 2 diabetes and its related epidemic. Having either parent obese is an independent risk factor for childhood obesity. Although the detrimental impacts of diet-induced maternal obesity on adiposity and metabolism in offspring are well established, the extent of any contribution of obese fathers is unclear, particularly the role of non-genetic factors in the causal… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice.
TLDR
These studies provide evidence that the heritability of body length and glucose homeostasis are modulated by maternal diet across multiple generations, providing a mechanism where length can increase rapidly in concert with caloric availability. Expand
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
TLDR
Maternal undernutrition during pregnancy (F0) programs reduced birth weight, IGT, and obesity in both first- and second-generation offspring. Expand
Early life influences on obesity risk: maternal overnutrition and programming of obesity
  • M. Morris
  • Medicine
  • Expert review of endocrinology & metabolism
  • 2009
TLDR
This review summarizes recent evidence of the impact of maternal obesity on subsequent obesity risk, paying particular attention to the hypothalamic regulation of appetite and markers of metabolic control. Expand
Diet-Induced Obesity in Male Mice Is Associated with Reduced Fertility and Potentiation of Acrylamide-Induced Reproductive Toxicity1
TLDR
It is demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity. Expand
Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect?
TLDR
This study demonstrates the important role of early nutrition on body weight and metabolism, suggesting early undernourishment enhances insulin sensitivity and fatty-acid oxidation. Expand
Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific.
TLDR
The studies show that LP dietary insult in early, middle, or late gestation, all result in a relative deficiency of beta cells following birth, due to a failure to develop larger islets, but that females were particularly susceptible in mid-gestation and males in late gestation. Expand
Genetic and Environmental Influences on Human Cord Blood Leptin Concentration
TLDR
Cord blood leptin concentration is elevated in the presence of a family history of obesity on the paternal side, but not on the maternal side, and may help clarify the role of leptin in parental contributions to human obesity. Expand
The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease
TLDR
It is proposed that genetically determined insulin resistance results in impaired insulin-mediated growth in the fetus as well as insulin resistance in adult life, which could result in lower birthweight. Expand
Childhood obesity: are genetic differences involved?
  • C. Bouchard
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 2009
TLDR
This brief review focuses on the genetic contribution to childhood obesity, and suggests that the prevalence of childhood obesity is increasing across generations as a result of positive assortative mating with obese husbands and wives contributing more obese offspring than normal-weight parents. Expand
Parental diabetes and birth weight of offspring: intergenerational cohort study
TLDR
This large cohort study of British births in 1958 was used to evaluate whether a father's non-insulin dependent diabetes or a mother's diabetes starting after childbirth is associated with the birth weight of their offspring. Expand
...
1
2
3
4
5
...