Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.

@article{Chen1996ChronicHB,
  title={Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.},
  author={C. J. Chen and M W Yu and Yun-Fan Liaw and Lian Wen Wang and S Chiamprasert and Farzana Matin and Ari Hirvonen and Douglas A. Bell and Regina M. Santella},
  journal={American journal of human genetics},
  year={1996},
  volume={59 1},
  pages={128-34}
}
This study was carried out to elucidate the effect of glutathione S-transferase (GST) Ml and Tl polymorphisms on the aflatoxin-related hepatocarcinogenesis among chronic carriers of hepatitis B surface antigen (HBsAg). A total of 32 newly diagnosed hepatocellular carcinoma (HCC) cases and 73 age-matched controls selected from a cohort of 4,841 chronic HBsAg carriers who had been followed for 5 years were studied. The level of aflatoxin B1 (AFB1)-albumin adducts in their serum samples collected… CONTINUE READING
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