Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability.

@article{RodriguezSosa2002ChronicHI,
  title={Chronic helminth infection induces alternatively activated macrophages expressing high levels of CCR5 with low interleukin-12 production and Th2-biasing ability.},
  author={Miriam Rodriguez-Sosa and Abhay R Satoskar and Rodrigo Calder{\'o}n and Lorena G{\'o}mez-Garc{\'i}a and Rafael Saavedra and Rafael Bojalil and Luis I Terrazas},
  journal={Infection and immunity},
  year={2002},
  volume={70 7},
  pages={3656-64}
}
Helminth infections induce Th2-type biased immune responses. Although the mechanisms involved in this phenomenon are not yet clearly defined, antigen-presenting cells (APC) could play an important role in this process. Here, we have used peritoneal macrophages (F4/80+) recruited at different times after challenge with Taenia crassiceps as APC and tested their ability to regulate Th1/Th2 differentiation. Macrophages from acute infections produced high levels of interleukin-12 (IL-12) and nitric… CONTINUE READING

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