Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice.

@article{Drouin2008ChronicHR,
  title={Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice.},
  author={Annick Drouin and M-E Gendron and Eric Thorin and M-A Gillis and Florence Mahlberg-Gaudin and J C Tardif},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 4},
  pages={749-57}
}
BACKGROUND AND PURPOSE High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with coronary artery disease. We tested the hypothesis that a reduction of resting heart rate with the cardiac pacemaker I(f) current inhibitor ivabradine prevents the endothelial dysfunction associated with dyslipidaemia. EXPERIMENTAL APPROACH Three-month-old dyslipidaemic (DL) male mice expressing the human ApoB-100 were assigned or not (DL, n=16… CONTINUE READING
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