Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.

@article{Martinez2010ChronicHF,
  title={Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.},
  author={Paula Felippe Martinez and Katashi Okoshi and Leonardo Ant{\^o}nio Mamede Zornoff and Robson Francisco Carvalho and Silvio de Assis Oliveira J{\'u}nior and Aline Regina Ruiz Lima and Dijon Henrique Salom{\'e} de Campos and Ricardo Luiz Damatto and Carlos Roberto Padovani and C{\'e}lia Regina Nogueira and Maeli Dal Pai-Silva and Marina Politi Okoshi},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2010},
  volume={16 12},
  pages={BR374-83}
}
BACKGROUND Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the expression of myogenic regulatory factors (MRF), myosin heavy chain (MyHC) isoforms, and fiber trophism in the soleus muscle of rats with myocardial infarction-induced heart failure. METHOD/RESULTS Six months after surgery, 2 groups of rats were studied: sham, and infarcted… CONTINUE READING
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