Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes

@article{Eastwood1997ChronicHT,
  title={Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes},
  author={Sharon L. Eastwood and J Timothy Heffernan and Paul J. Harrison},
  journal={Molecular Psychiatry},
  year={1997},
  volume={2},
  pages={322-329}
}
Synaptophysin is a protein used as a marker of presynaptic terminals. We previously showed that, in dorsolateral striatum of the rat, 2 weeks’ haloperidol treatment up-regulated synaptophysin mRNA. We have now investigated the effects of 16 weeks’ treatment with haloperidol on synaptophysin expression in dorsolateral striatum, frontoparietal cortex and hippocampus, in order to see if the implied haloperidol-induced synaptic plasticity persists. For comparison, in both the 2- and 16-week… CONTINUE READING
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