• Medicine
  • Published in
    Brain research. Molecular…
    1993

Chronic haloperidol does not alter G protein alpha-subunit levels in rats.

@article{See1993ChronicHD,
  title={Chronic haloperidol does not alter G protein alpha-subunit levels in rats.},
  author={Ronald E. See and Caryn D. Striplin and Peter W. Kalivas},
  journal={Brain research. Molecular brain research},
  year={1993},
  volume={19 3},
  pages={
          219-21
        }
}
Female Sprague-Dawley rats were administered continuous haloperidol or no drug for 32 weeks via subcutaneous silastic implants. Three days after drug withdrawal, animals were rapidly decapitated and tissue samples were analyzed for levels of G alpha subunits for Gi and Gs using immunoblotting procedures. No significant differences were seen between groups in the dopaminergic terminal regions of the medial prefrontal cortex, nucleus accumbens, or dorsolateral caudate-putamen. These results… CONTINUE READING