Chronic granulomatous disease of childhood: clinical, pathological, biochemical, molecular, and genetic aspects of the disease.

Abstract

The pathobiology of chronic granulomatous disease (CGD) of childhood, a heterogeneous phenotypic disorder characterized by chronic and recurrent infection, has become more completely understood over the past three decades. Blood neutrophils, monocytes, and eosinophils lack a respiratory burst required for effective killing of catalase positive bacteria by… (More)

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