Chronic granulomatous disease in two sisters

  title={Chronic granulomatous disease in two sisters},
  author={R D'amelio and Paolo Bellavite and Paolo Bianco and Pasquale De Sole and Soccorsa Le Moli and Silvio Lippa and Rosalba Seminara and Brunella Vercelli and Filippo Rossi and Giovanni Rocchi and Fernando Aiuti},
  journal={Journal of Clinical Immunology},
Two sisters with chronic granulomatous disease (CGD) have been studied. The diagnosis was suggested by the histopathological findings from the spleen and lymph nodes of the proband and confirmed by the low values obtained in the following tests performed on polymorphonuclear leukocytes (PMN): chemiluminescence, nitroblue tetrazolium (NBT) reduction, killing ofStaphylococcus aureus, and O 2 − production. NADPH oxidase activity was not detected in the homogenates of the patients' PMN but… CONTINUE READING