Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b.

Abstract

A patient with an X-linked genetic disease resembling chronic granulomatous disease (CGD) but differing in several aspects from previously studied cases is described. The oxidase enzyme of the patient's granulocytes was normally activated, but had reduced activity as shown by an increased Michaelis constant and decreased maximum velocity of NADPH-dependent… (More)

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@article{Seger1983ChronicGD, title={Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b.}, author={Reinhard A. Seger and Louis X Tiefenauer and Teiichi Matsunaga and Alexander Wildfeuer and Peter E. Newburger}, journal={Blood}, year={1983}, volume={61 3}, pages={423-8} }