Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.

  title={Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.},
  author={Premysl Bercik and Elena F. Verd{\'u} and Jane A. Foster and Joseph Macri and Murray Potter and Xunchun Huang and Paul M. Malinowski and Wendy Jackson and Patricia A Blennerhassett and Karen A Neufeld and Jun Lu and Waliul I Khan and I Corth{\'e}sy-theulaz and Christine Cherbut and Gabriela E. Bergonzelli and Stephen Michael Collins},
  volume={139 6},
BACKGROUND & AIMS Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and examined underlying mechanisms. METHODS AKR mice were infected with the noninvasive parasite Trichuris muris and given etanercept, budesonide, or specific probiotics. Subdiaphragmatic vagotomy was performed in a subgroup of mice before infection. Gastrointestinal… 

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