Chronic focal neocortical epileptogenesis: does disinhibition play a role?

@article{Prince1997ChronicFN,
  title={Chronic focal neocortical epileptogenesis: does disinhibition play a role?},
  author={David A. Prince and Kimberle M. Jacobs and Paul Antoine Salin and Stuart N. Hoffman and Isabel Parada},
  journal={Canadian journal of physiology and pharmacology},
  year={1997},
  volume={75 5},
  pages={500-7}
}
Several lines of evidence have suggested that decreases in postsynaptic inhibition may have a role in epileptogenesis in cortical structures. However, other studies have suggested that GABAergic inhibition is spared, or even augmented in some forms of post-lesional epilepsy. In the studies described here, inhibitory events were recorded in two models of post-lesional chronic epileptogenesis. (i) As previously reported (D.A. Prince and G.-F. Tseng. J. Neurophysiol. 69: 1276-1291. 1993… CONTINUE READING