Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam

@article{Pawluski2012ChronicFT,
  title={Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam},
  author={Jodi L Pawluski and Thierry D Charlier and Marianne Fillet and Virginie Houbart and Hilda T. Crispin and Harry W. M. Steinbusch and D.L.A. van den Hove},
  journal={Behavioural Brain Research},
  year={2012},
  volume={228},
  pages={159-168}
}
The incidence of stress and stress-related disorders with the transition to motherhood, such as postpartum depression, is estimated to be 20%. Selective serotonin reuptake inhibitor (SSRI) medications are currently the antidepressant of choice to treat maternal mood disorders. However, little is known about the effects of these medications on the maternal brain and behavior. Therefore, the present study investigated how a commonly used SSRI, fluoxetine, affects neurobehavioral outcomes in the… Expand
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Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring
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A prenatal stress model of maternal depression and its treatment
Rationale A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. Objective The objective of this study wasExpand
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