Chronic fatigue syndrome: a review.

  title={Chronic fatigue syndrome: a review.},
  author={Niloofar Afari and Dedra Buchwald},
  journal={The American journal of psychiatry},
  volume={160 2},
  • N. AfariD. Buchwald
  • Published 1 February 2003
  • Medicine, Psychology
  • The American journal of psychiatry
OBJECTIVE Chronic fatigue syndrome is an illness characterized by disabling fatigue of at least 6 months, accompanied by several other symptoms. This review summarizes the current state of knowledge about chronic fatigue syndrome. METHOD The case definition, prevalence, clinical presentation, evaluation, and prognosis of chronic fatigue syndrome are discussed. Research on the pathophysiology and treatment of chronic fatigue syndrome is reviewed. RESULTS Chronic fatigue syndrome is diagnosed… 

Tables from this paper

Clinical Practice: Chronic fatigue syndrome

The diagnosis CFS should be considered in any adolescent patient with severe disabling long-lasting fatigue, and cognitive behavioural therapy is effective in 60–70 % of the patients.

Chronic fatigue syndrome: aetiology, diagnosis and treatment

The main social and care needs for people affected with Chronic Fatigue Syndrome are pointed out to point out to prevent the problems derived from current systems.

Chronic fatigue syndrome Health and impairment, treatment and prognosis

Investigating a clinical population with neurasthenia and chronic fatigue syndrome, by assessing subjective health complaints, functional impairment and work disability, by examining treatment effects of specific interventions, by studying long-term illness course and by analyzing the comorbidity of depression and personality patterns showed substantial clinical improvement.

Chronic Fatigue Immune Dysfunction Syndrome : A Review

Recent work characterizing improved CFIDS biomarkers coupled with a modified understanding of CFIDS etiology may foreshadow a transformation in the medical approach to this illness.


Chronic Fatigue and Postinfective Fatigue Syndromes

Studies with patients with the overlapping clinical syndrome of fibromyalgia have demonstrated the benefit of a combination of a low-dose tricyclic antidepressant and a nonsteroidal anti-inflammatory agent, arguing for a similar therapeutic trial in patients with chronic fatigue syndrome in whom pain and sleep disturbance are prominent.

Causes and consequences of autonomic dysfunction in Chronic Fatigue Syndrome

It is suggested that elucidating the symptoms seen in CFS will support research into its underlying pathophysiology and enable more tailored treatment, and the need to better understand the underpinning causality to allow appropriate identification and management.

Neural Dysfunction in Chronic Fatigue Syndrome

Data from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction in CFS suggest that the central nervous system is primarily involved in the pathophysiology of CFS and proposes a treatment strategy on the basis of these suggested underlying neural mechanisms.



The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons

The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study.

Both chronic fatigue and chronic fatigue syndrome are common in primary care patients and represent a considerable public health burden and selection bias may account for previous suggestions of a link with higher socioeconomic status.

Neuropsychological deficits in chronic fatigue syndrome: artifact or reality?

A comprehensive summary and discussion of the results from neuropsychological studies which have compared patients with chronic fatigue syndrome with controls or normative data are provided to provide both some clarity in the area and directions for future research.

A family history study of chronic fatigue syndrome

It is suggested that familial factors are important in the aetiology of chronic fatigue syndrome, and whether the high rate of comorbid depression in CFS is reflected in a greater familial loading for affective disorder.

Chronic fatigue syndrome: a working case definition.

A new name is proposed for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue.

Neuroendocrine correlates of chronic fatigue syndrome: a brief review.

  • M. Demitrack
  • Psychology, Medicine
    Journal of psychiatric research
  • 1997

Chronic fatigue, chronic fatigue syndrome, and fibromyalgia. Disability and health-care use.

Patients with chronic fatigue, CFS, FM, and CFS+FM were similar in terms of disability and health-care use, though those with CFS +FM were significantly more likely to be unemployed and to use more chiropractic and "other" provider services.

The prognosis of chronic fatigue and chronic fatigue syndrome: a systematic review.

A systematic review of all studies to determine the proportion of individuals with the conditions who recovered at follow-up, the risk of developing alternative physical diagnoses, and the risk factors for poor prognosis found that older age, more chronic illness, having a comorbid psychiatric disorder and holding a belief that the illness is due to physical causes are consistent.

Chronic fatigue syndrome. 1: Etiology and pathogenesis.

An accurate case definition identifying homogeneous subtypes of CFS is needed and the integration of medical and psychologic treatment modalities and the use of both biologic and Psychologic markers to evaluate treatment response will enhance future treatment strategies.

Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting.

Both chronic fatigue and chronic fatigue syndrome are associated with previous psychiatric disorder, partly explained by high rates of current psychiatric disorder.