Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the rat.

  title={Chronic failure in the maintenance of long-term potentiation following fluid percussion injury in the rat.},
  author={Matthew J. Sanders and Thomas J. Sick and Miguel A. P{\'e}rez-Pinz{\'o}n and W. Dalton Dietrich and Edward J. Green},
  journal={Brain research},
  volume={861 1},
Traumatic brain injury (TBI) can produce chronic cognitive learning/memory deficits that are thought to be mediated, in part, by impaired hippocampal function. Experimentally induced TBI is associated with deficits in hippocampal synaptic plasticity (long-term potentiation, or LTP) at acute post-injury intervals but plasticity has not been examined at long-term survival periods. The present study was conducted to assess the temporal profile of LTP after injury and to evaluate the effects of… CONTINUE READING


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