Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance.

Abstract

UNLABELLED In most autoimmune diseases the serologic hallmarks of disease precede clinical pathology by years. Therefore, the use of animal models in defining early disease events becomes critical. We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNγ) characterized by prolonged and chronic expression of IFNγ through deletion… (More)
DOI: 10.1002/hep.28641

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