Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts.

@article{Holmes2010ChronicET,
  title={Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts.},
  author={Amie L. Holmes and Sandra S. Wise and Stephen C. Pelsue and AbouEl-Makarim Aboueissa and Wilma L. Lingle and Jeffery L. Salisbury and Jamie Gallagher and John Pierce Wise},
  journal={Chemical research in toxicology},
  year={2010},
  volume={23 2},
  pages={
          386-95
        }
}
Hexavalent chromium (Cr(VI)) compounds are known human lung carcinogens. Solubility plays an important role in its carcinogenicity with the particulate or insoluble form being the most potent. Of the particulate Cr(VI) compounds, zinc chromate appears to be the most potent carcinogen; however, very few studies have investigated its carcinogenic mechanism. In this study, we investigated the ability of chronic exposure to zinc chromate to induce numerical chromosome instability. We found no… CONTINUE READING

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