Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice.

Abstract

Interaction of genetic and environmental factors is likely involved in Parkinson's disease (PD). Mutations and multiplications of alpha-synuclein (α-syn) cause familial PD, and chronic manganese (Mn) exposure can produce an encephalopathy with signs of parkinsonism. We exposed male transgenic C57BL/6J mice expressing human α-syn or the A53T/A30P doubly… (More)
DOI: 10.1016/j.neuroscience.2011.02.017

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