Chronic exposure to low concentrations of halothane-nitrous oxide: lack of carcinogenic effect in the rat.

@article{Coate1979ChronicET,
  title={Chronic exposure to low concentrations of halothane-nitrous oxide: lack of carcinogenic effect in the rat.},
  author={W B Coate and B. M. Ulland and Tracy R. Lewis},
  journal={Anesthesiology},
  year={1979},
  volume={50 4},
  pages={306-9}
}
The effects of prolonged exposure to low-concentration combinations of halothane and nitrous oxide on tumor incidence, especially with regard to the reticuloendothelial system, were studied. Three groups of 50 male and 50 female Fischer 344 rats each were studied. For seven hours/day, five days/week, for 104 weeks, Group I was exposed to filtered air (control); Group II, to halothane, 1 ppm, and nitrous oxide (N2O), 50 ppm; Group III, to halothane, 10 ppm, and N2O, 500 ppm. No evidence of… CONTINUE READING

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