Chronic exposure to lead causes persistent alterations in the electric membrane properties of neurons in cell culture.

The effects of chronic lead (Pb) exposure on neuronal electric membrane properties (EMP) were determined using neural cell cultures of adult mouse dorsal root ganglia (DRG). Cultures were exposed to Pb concentrations ranging from 0 to 100 microM for 12 days (8 DIV to 20 DIV). EMP were determined in Pb-free medium either immediately after withdrawal (IWD… CONTINUE READING