Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells.

Abstract

Dyslipidemia is a common metabolic disorder in diabetes. Nitric oxide (NO) production from endothelium plays the primary role in endothelium-mediated vascular relaxation and other endothelial functions. Therefore, we investigated the effects of elevated free fatty acids (FFA) on the stimulation of NO production by phospholipase C (PLC)-activating receptor… (More)
DOI: 10.1530/JME-11-0082

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@article{Tang2011ChronicET, title={Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells.}, author={Yanxia Tang and Guodong Li}, journal={Journal of molecular endocrinology}, year={2011}, volume={47 3}, pages={315-26} }