Chronic exposure to dexamethasone induces hypomethylation of ornithine decarboxylase genes in a human myeloma cell line.

Abstract

Chronic exposure of a human myeloma cell line to dexamethasone resulted in a selection of cells resistant to the growth-inhibitory action of the glucocorticoid. Upon acute exposure of the parental myeloma cells to dexamethasone growth inhibition was associated with depression of ornithine decarboxylase (ODC, EC 4.1.1.17) activity. However, in cells adapted… (More)

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@article{Leinonen1987ChronicET, title={Chronic exposure to dexamethasone induces hypomethylation of ornithine decarboxylase genes in a human myeloma cell line.}, author={Pekka E. Leinonen and Leena Alhonen-Hongisto and Richard M Laine and Olli A. J{\"a}nne and Juhani E J{\"a}nne}, journal={FEBS letters}, year={1987}, volume={215 1}, pages={68-72} }