Chronic exposure to benzene results in a unique form of dysplasia.

  title={Chronic exposure to benzene results in a unique form of dysplasia.},
  author={Richard D. Irons and Ling Lv and Sherilyn A Gross and Xibiao Ye and Liming Bao and Xiao Qin Wang and John Ryder and Thomas W. Armstrong and Yimei Zhou and Lizhaung Miao and Anh Tuan Tran Le and Patrick J Kerzic and Weimin Ni and Hua Fu},
  journal={Leukemia research},
  volume={29 12},
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workers exposed to high concentrations of benzene. Distinguishing features of benzene-induced dysplasia include: marked dyserythropoiesis, eosinophilic dysplasia and abnormal cytoplasmic granulation of neutrophilic precursors. Hematophagocytosis, stromal degeneration and bone marrow hypoplasia are also seen… CONTINUE READING


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