Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells.

@article{HettingerSmith1996ChronicET,
  title={Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells.},
  author={B D Hettinger-Smith and Mark E Leid and Thomas F. Murray},
  journal={Journal of neurochemistry},
  year={1996},
  volume={67 5},
  pages={1921-30}
}
Chronic treatment with the adenosine receptor antagonist caffeine evokes an up-regulation of A1 adenosine receptors and increased coupling of the receptor to G proteins in rat brain membranes. However, chronic agonist exposure has not been explored. Primary cultures of cerebellar granule cells were exposed chronically to A1 adenosine receptor agonists and… CONTINUE READING